For more information on the possible side effects of methadone, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

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Switching a patient from another chronically administered opioid to methadone requires caution due to the uncertainty of dose conversion ratios and incomplete cross-tolerance. Deaths have occurred rein opioid tolerant patients during conversion to methadone. Conversion ratios hinein many commonly used equianalgesic dosing tables do not apply hinein the Schauplatz of repeated methadone dosing.

Since methadone is lipophilic, it has been known to persist in the liver and other tissues. The slow release from the liver and other tissues may prolong the duration of methadone action despite low plasma concentrations.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should Beryllium aware that addiction may not Beryllium accompanied by concurrent tolerance and symptoms of physical dependence hinein all addicts. Hinein addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances.

Do not take a higher dose of methadone hydrochloride tablets or take it more often than prescribed. This can lead to an overdose and possible death.

Extreme caution is necessary when any Erhaltungstherapie mit Methadontabletten drug known to have the potential to prolong the QT interval is prescribed hinein conjunction with methadone.

In using methadone an individualized benefit to risk assessment should Beryllium carried out and should include evaluation of patient presentation and complete medical history.

The decrease hinein plasma half-life and increased clearance of methadone resulting rein lower methadone trough levels during pregnancy can lead to withdrawal symptoms rein some pregnant patients. The dosage may need to Beryllium increased or the dosing interval decreased rein pregnant patients receiving methadone (Teich PRECAUTIONS, Pregnancy, Laboratorium and Delivery, and DOSAGE AND ADMINISTRATION).

Infants born to mothers physically dependent on opioids may also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (Tümpel PRECAUTIONS, Pregnancy, Laboratorium and Delivery).

Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly during the initial dosing period.

Methadone should Beryllium administered with particular caution to patients already at risk for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia). Careful monitoring is recommended when using methadone hinein patients with a history of cardiac conduction abnormalities, those taking medications affecting cardiac conduction, and rein other cases where history or physical exam suggest an increased risk of dysrhythmia. QT prolongation has also been reported rein patients with no prior cardiac history Weltgesundheitsorganisation have received high doses of methadone.